MICROBIOLOGICAL ASSAY FOR THYMINE USING A MUTANT OF STREPTOCOCCUS FAECALIS

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Microbiological assay for thymine using a mutant of Streptococcus faecalis.

Doctor, V. M. (University of Texas, Houston). Microbiological assay for thymine using a mutant of Streptococcus faecalis. J. Bacteriol. 84:17-22. 1962.-A rapid microbiological assay procedure for the determination of thymine was devised. The test organism, Streptococcus faecalis Akt, a mutant of S. faecalis ATCC 8043, gives one-half the maximal growth response to 1.6 mug of thymine (assay range...

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Recombination-deficient mutant of Streptococcus faecalis.

An ultraviolet radiation-sensitive derivative of Streptococcus faecalis strain JH2-2 was isolated and found to be deficient in recombination, using a plasmid-plasmid recombination system. The strain was sensitive to chemical agents which interact with deoxyribonucleic acid and also underwent deoxyribonucleic acid degradation after ultraviolet irradiation. Thus, the mutant has properties similar...

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The utilization of dihydrothymine by Streptococcus faecalis in the absence of folic acid and thymine.

Stokes (1944) reported the replaceability of folic acid by thymine for Streptococcus lactis strain R as well as other folic-acid-requiring streptococci, and Fink et al. (1954) noted that high concentrations of recrystallized dihydrothymine supported growth of Streptococcus faecalis (ATCC 8043) deficient in both folic acid and thymine. The question arose, however, as to whether the latter respon...

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Phospholipids of Streptococcus faecalis.

Autoradiograms of total lipid extracts from Streptococcus faecalis ATCC 9790, harvested in the stationary phase from a medium containing (32)P-orthophosphate, showed six major spots. The corresponding compounds were identified as diphosphatidylglycerol (possibly with a penta acyl structure); phosphatidylglycerol; a provisionally identified mixture of alanylphosphatidylglycerol and of the 2'-lys...

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A Differential Microbiological Assay

Although vitamin B12 can be assayed biologically with mice, chicks or rats, the microbiological method of assay is preferred since it is more rapid and economical. One serious shortcoming of many microbiological B12 assay procedures is the lack of specificity when crude materials are assayed. Crude materials can contain inhibitory or stimulatory factors which cause serious errors in assay resul...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1962

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.84.1.17-22.1962